Structure-activity analysis of the Pseudomonas quinolone signal molecule.
نویسندگان
چکیده
We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 192 14 شماره
صفحات -
تاریخ انتشار 2010